摘要：Objective: To discuss the effect of low molecular weight heparin sodium on children with primary nephrotic syndrome. Method: Divided the 97 children with primary nephrotic syndrome who were treated in my hospital from Jan. 2009 to Oct. 2010 into two groups randomly. Patients in the control group received routine treatment, Therapeutic drugs includes prednisone, diuretics, lipid-lowering drugs, angioten-sin-converting enzyme inhibitor and so on. On the medical basis of the control group, the patients in the experimental group used the low molecular weight heparin sodium. Compared the treatment effect of the two groups, and anlyzed the urinary protein, f ibrinogen, albumin of the children. The results were processed u-sing statistics. Result: After the clinical treatment, 48 patients in the experimental group, 21 patients remitted completely, 16 patients remitted partly, the total efficiency was 77.08% ; Among the 49 patients in the control group, 9 patients remit completely, 16 patients remit partly, the total efficiency was 51. 02% , patients in the experimental group were better than the control group. According to the statistical analysis, P < 0. 05. The urinary protein and fibrinogen of the patients in the experimental group dropped, and the albumin rose. Compared with the control group, the difference was notable, P<0.05. Conclusion: In the treatment of the children with primary nephrotic syndrome, low molecular weight heparin has and better effect, which is worth promoting in clinical.%目的:探討采用低分子量肝素鈉對兒童原發性腎病綜合征的治療效果.方法:將我院2009年1月至2010年10月收治的97例兒童原發性腎病綜合征患者隨機分為兩組.對照組患者給予常規治療方法,治療藥物包括強的松、利尿劑、降脂藥物、血管緊張素轉換酶抑制劑等.實驗組患者在對照組患者用藥基礎上,使用低分子量肝素鈉治療.比較兩組患者的治療效果,并對患兒尿蛋白、血纖維蛋白原、血白蛋白進行分析.將結果使用統計學處理.結果:實驗組患者48例經過臨床治療后,患者完全緩解21例,部分緩解16例,總有效率為77.08%;對照組患者49例,完全緩解9例,部分緩解16例,總有效率為51.02%,實驗組患者療效明顯優于對照組,經統計學分析,P<0.05.觀察組患者的尿蛋白、血纖維蛋白下降,血清白蛋白上升,與對照組比較,差異顯著,P<0.05.結論:在治療兒童原發性腎病綜合征時,為患者提供低分子量肝素,效果更好,值得在臨床推廣使用.